Inactive chromatin spreads from a focus of methylation.
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چکیده
منابع مشابه
Chromatin Structure of the Inactive X Chromosome
X-inactivation is the unusual mode of gene regulation by which most genes on one of the two X chromosomes in female mammalian cells are transcriptionally silenced. The underlying mechanism for this widespread transcriptional repression is unknown. This thesis investigates two key aspects of the X-inactivation process. The first aspect is the correlation between chromatin structure and gene expr...
متن کاملMethylation of chromatin DNA.
E. coli DNA methylase has been used to methylate chromatin DNA in vitro. At saturation only 50% of the chromatin DNA becomes methylated. The methylated regions of chromatin correspond to that fraction of the chromatin which is sensitive to staphylococcal nuclease. Using in vitro methylated chromatin followed by nuclease digestion movement of chromatin proteins along the DNA can be detected. By ...
متن کاملHistones of Genetically Active and Inactive Chromatin
It has frequently been proposed that a variation in the relative content of lysine-rich, moderately lysine-rich, and arginine-rich histones might provide a mechanism by which specific portions of the genome may be genetically regulated. This possibility was investigated by comparing the electrophoretic pattern of these three fractions in cells differing markedly in their content of genetically ...
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Der Aufbau des Nukleosoms als Grundbaustein des Chromatins der Eukaryontenzelle, mit Ausnahme des Dinoflagellaten-Zellkerns, wird biochemisch und elektronenmikroskopisch vorgestellt als eine Einheit eines Oktamers aus Histonen (2 X H2A, 2XH2B, 2X H3, 2X H4) und einem Betrag von etwa 150 Basenpaaren DNA. Diese Partikel sind durch einen Zwischenbereich von weiteren etwa 50 Basenpaaren DNA verbund...
متن کاملL3MBTL1, a Histone-Methylation-Dependent Chromatin Lock
Distinct histone lysine methylation marks are involved in transcriptional repression linked to the formation and maintenance of facultative heterochromatin, although the underlying mechanisms remain unclear. We demonstrate that the malignant-brain-tumor (MBT) protein L3MBTL1 is in a complex with core histones, histone H1b, HP1gamma, and Rb. The MBT domain is structurally related to protein doma...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1993
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.13.12.7372